Throughout some episodes, there are occasional sexual themes and references. They are usually used to explain situations or as jokes.

The hosts talk about very disturbing topics, such as murder or torture. In some cases, they describe the aftermath of certain crimes, such as the bodies of the victims of serial killers, in detail, which can be disturbing to some viewers. However, actual violence or gore is rarely explicitly shown.

One episode usually contains some strong language. (For example, an episode usually has 2 - 7 "F-words," and 5 - 15 "S-words.")

38 f*** words

Occasional drug references, mainly in an educational or joking way.

Many of the cases described can be very scary and disturbing to some, but the comedic overtones help lighten the mood.