Jesse flirts with a lot of women.

In the first season, Jesse is portrayed as having intimate, physical relationships with many women.

One episode focuses on the topic of child abuse when Michelle is partnered with a classmate who is a victim of child abuse at one point in the episode he talks about thinking about funny movies as a distraction when his father beats him this may trigger viewers who are victims of child abuse.

There is virtually no violence.

In one episode in season eight, "disco sucks" is said, though it refers more to the actual campaign "Disco Sucks" than the actual statement.

"Hell" is said occasionally throughout the series, much more frequently in the first season. It means both the place and it is in expletives such as "what the hell". "Damn" is said only a few times in season one, and "jackass" is said in two episodes, though one refers directly to a donkey.

Name-calling, such as "bonehead", "duckface", "fatboy".

In a blooper reel for the show, found on Youtube for the episode "Jingle Hell", Jesse(John Stamos) says" Have you ever seen that show "My two Dads?", he flubs his line by saying" Have you ever seen that show "My three Dads?", by mistake. Joey(Dave Coulier , in said blooper responds with" Yeah, it's called 'Full House', you dipshit".

In "Sisterly Love". Danny and Joey discruss smoking by saying" I've known you for years, when did you smoke?" Joey replies" When I was 12; I smoked 4 cigarettes, my Dad stopped me cold turkey."

There is one episode where DJ catches a friend drinking beer. She takes it away from them and when Jesse catches her with it in her hand she is accused of doing the same.

In one episode, Kimmy is seen drunk and later hungover.

In Season Seven, Episode Five, "Fast Friends", teens try to convince Stephanie to smoke.

A young boy talks about being abused by his father which can be triggering to abuse survivors.

The episode where Papouli dies is very sad.

Although this is a light hearted family friendly show some episodes deal with heavy topics such as death, bullying, child abuse, and eating disorders.