There is no nudity, other than men taking off their shirts (most-often in Doc's office).

In early episodes, it's implied that some of the Long Branch's dance-hall girls are prostitutes -- including (by association) Miss Kitty. (This was not true of the real Long Branch.) Sex between men and women is implied, but couples are never shown in bed together.

Festus' girlfriend is raped (off-screen) in one episode. Miss KItty is raped in at least two of the color episodes ("Mannon" and "Hostage!"). She indicates in one episode that Matt isn't the only man she loves (the implication being that "love" includes sex).

The violence of both the radio and TV series can be described with two adjectives -- unvarnished and blunt. (Episode-specific details deleted.)

Even the principals can be guilty of murder.

As the series "matured", lengthening into hour-long episodes, then acquiring color, there was less violence -- but not necessarily less-extreme violence.

(Deleted. Personal opinions about ratings are not appropriate for the Parents Guide.)

"Dang!" appears to be the closest any script comes to profanity.

Damn and Hell are used in some of the color episodes. Festus frequently uses "Sam Hill" which sometimes sounds like "Sam Hell" Jackass may be used referring to Mules and Donkeys, but I'm not sure

Beer and hard liquor flow freely in the Long Branch. Male characters commonly smoke, though none of the principals do.

Death is common. "Graphic" deaths and on-screen torture are not shown.