Some characters smoke throughout the series. In one episode, Pickles brings Ritchie some chocolate cigarettes.
Characters sometimes drink throughout the series. Mostly wine at parties, and there are a couple episodes with beer.
In one episode (My Husband is a Drunk), Rob is hypnotized so that he acts drunk. He is not actually drunk, though.
There is one episode (Pink Pills and Purple Parents) that Laura takes Millie's prescription medicine and it affects her badly. She acts like she is drunk, but she is not, it is just from the medicine.