The show features heavy drinking at times, for example before or after a soccer match. The character Xavier Waterslaeghers, in particular, goes completely over the edge most of the times sending the wrong message to young children in doing so. One character, Carmen, is addicted to small cigars and drinks port wine regularly. Balthazar Boma regularly drinks a strong beer. Of course, within the setting, it can be expected.
Drugs, neither hard nor soft, are not an issue at all. They are only referenced a few times. Alcohol is a major issue, smoking a minor (the first seasons in particular). The show aired in an era where smoking was allowed in public places, such as a clubhouse of a soccer team like it is the case here. All of its titles are from that era. On June 30, 2011 smoking in public places was banned. The last title aired in February 2011 and filming concluded in 2010.
In one episode, the title character Oscar Crucke takes it personal that he can not coach the soccer team properly on his own, and can not stand a moral psychologist should improve the team's poor results. He turns to alcohol and did the same thing when told he cannot drink. The character gets pushed into drinking alcohol. There is an urge to prove others.
An episode revolves around characters tasting beers which culminates in getting drunk together (quite late in the show's run).
An episode deals with two husbands escape a sermon from their wives by getting drunk together and quietly spend the night at a character's place without his knowledge (burglary by law, basically). The booze is responsible for the deeds committed.
An episode sees a woman collapsing from alcohol abuse when persuaded into drinking further, or the other way around, not being stopped doing it by four male characters who had the opportunity to do just that. This includes the title character, the pub owner. The reason they do not tell her is they want to fool a man she is to have a date with.