The series has a decent number of nude scenes with female characters. Beyond usually having detailed topless nudity, this doesn't get too explicit.

Lupin is shown to be a ladies man throughout the series, with Fujiko often being the target of his affections. He makes attempts to seduce and undress her at points, with Fujiko often comically rebuffing his advances.

Fujiko is occasionally seen dressed in some fairly skimpy outfits and using her attractive looks to manipulate male criminals to trust and aid her in her schemes to get valuable items.

The series has a good amount of gunfire and swordplay for its action. Many episodes play these scenes up for comedy with no characters being seriously harmed. But there are occasional serious episodes that depict characters being harmed or killed, having a fair amount of blood spilled during said violent moments.

The series depicts characters smoking and drinking fairly often, the latter resulting in them getting into varying degrees of intoxication played up for comical effect.