NEVER is there any real nudity, partial or otherwise. Girls wear some suggestive outfits, that's about limit.

A woman is stabbed in the stomach by a man who turns out to be a demon

Demons are killed in fireballs, one is dismembered by having his limbs blown up graphically

They are not at all afraid to use profanity. In every episode. They will use hell, damn, ass, and sometimes bitch.

They drink. Their father smokes cigars.

Sometimes has very intense scenes dealing with death and dying. You see the sisters break down and cry when certain characters die. The actresses are very good, and could easily make the viewers cry as well. Could be hard to watch at times.

Demons fight witches