In one episode, Reba accidently takes one of Cheyenne's anti-drinking pills, which makes the person who takes it sick it they drink alcohol. So as a cover-up, Van drinks all of Reba's drinks to avoid making her sick, Van later becomes drunk. This scene is mainly played for laughs.
Van, Reba and Barbra Jean occasionally drink alcohol, Brock reveals that because of the trouble the divorce has caused he drinks.
One episode focuses on Cheyenne being an alcoholic, and she later smokes cigarettes.
Brock reveals that he used to smoke cigarettes before Cheyenne was born.
One episode focuses on marijuana use.