Zorak makes various references to sex throughout the show, and has sex in the episode "Pepper."
Brak and his friend Clarence try to get laid by living in cardboard boxes in "Cardburkey", and Clarence has sex with a bloodcat that turned out to be a god's girlfriend that approaches Brak.
Violence & Gore
Mild
Very little, Zorak is blown up in almost every episode, but no blood is shown, and it is in a very cartoony fashion.
Profanity
Mild
Yes, but all profanities above "bitch" are bleeped.
Alcohol, Drugs & Smoking
Mild
Zorak tells Brak that they are going to get some beer behind their parents back in the pilot, but Brak doesn't know what this is and agrees.
Zorak, in a parody of 1960s sitcoms, tells Mom to get him a highball, and Dad wants a cigarette instead.
Dad smoked at an ice cream store he worked at (even though he couldn't smoke in there) and blew smoke right in his son's face, and put it out in the ice cream.