Squidbillies contains surreal but graphic content that while mainly comedic it can be frightening, disgusting or horrifying to certain people.

Scenes of crude and surreal, but comical sexual content, references and nudity are seen in several episodes; however most of the time sexual references populate the show.

A running gag has Early's hat saying or depicting some sexually charged images or graphics.

Brutal, bloody cartoon violence is frequent. Gun violence; beatings, murder and other violent conflicts are seen throughout, but most of the violence is meant to be humorous.

"Goddamn" was censored until season 8.

"Shit" was censored until season 9.

Frequent language includes uses of "bastard', "slut" "bitch" and other assorted mild profanities like "damn" and "hell". Racial slurs and stereotypes are common; but this is played for laughs. Anything stronger is bleeped.

Drugs, alcohol and smoking are scattered in the series, including a character that operates a meth lab; a chain-smoking cop and assorted alcohol consumption that can lead to comical drunken behavior.

Throughout the show, a character is verbally and physically abusive towards his entire family, especially his son. Sensitive viewers may find this frightening. However this is played for laughs.

Squidbillies, while mainly comical in it's premise is extremely surreal and strange; and contains moments that can be very shocking and gruesome. The violence, racism and stereotypes can be offensive to some.