Though this anime has some dark humor, overall this anime is really depressing. It deals with serious subjects such as depression, desperation, loneliness, existential crisis, isolation etc.
The main protagonist is a nervous wreck, he has visions of his kitchen appliances coming to life. Not intended to be disturbing, but it might freak some people out.
A few attempted suicides. Might upset some.
All of the sexual references and scenes might upset some.