Sex and relationships are a frequent subject on the show. Some characters are nude at times, however the camera angles keep us from seeing anything overly revealing - characters butts are the worst thing we see.
If you've seen any other animated sitcom (Simpsons, King of the Hill, etc.) you have a pretty good idea of what to expect here.
Violence & Gore
Mild
Typical schoolyard bullying and mild violence. Much of the violent content is slapstick and mostly comical.
Profanity
Mild
Mild language and anatomical terms. Again, no worse than most other popular animated sitcoms.
Alcohol, Drugs & Smoking
Moderate
Some episodes do feature teenage characters partying and getting drunk, though this is played more for laughs than anything else.
Frightening & Intense Scenes
None
None really. This is a comedy and it never takes itself too seriously.