A girl is sexually harassed by a teacher, there is nothing explicit but the man is stopped by another student.

On Episode 5, a man dissects a woman and her upper body and lower back can be seen briefly for a couple of secs, although it obscured by light.

A main female character has a rather large bust size. This is talked about throughout the series

One or two shower scenes, brief upper Female nudity.

Some of the fights are a little bloody, but serious injuries tend not to occur.

Some strong language (which is more than the usual TV-14 show) in the dub, not a lot in the subtitled version.

In the dub: damn, hell, bastard, ass, bitch. Quite a few uses of shit.

Shizuo often smokes and the way he does it makes it look cool which may offend some parents.

A girl has her leg broken, realistic sounds are heard. A regenerative girl is non-graphically vivisected in a rather perverse scene.

Characters include a (sexually) warped scientist, and to a lesser degree, a smirking villain.

A slasher attacks random people, although none are killed.

PG-13 to R for some violence, sexual nudity, and brief language.