Conan makes frequent jokes about sex. In some of the clueless gamer segments, there is some nudity (which is blurred) and other things about sex such as strip clubs in GTA V. However, most of the humor is pretty tame.

Some skits have violence such as the clueless games in which Conan plays violent games such as GTA and Call of Duty

Strong swear words like fuck and cunt are bleeped, while mild words like hell, damn, bitch, dick (as an insult) and shit are heard.

He smokes 64 cigars on the show.