Same-sex kissing.

There is a transexual charecter. Lisa asks "how does it work?" and Gladys answers "They just tuck everything in". It's not that sexual and it could float over younger viewers minds.

Some sexual talk and pre-sex scenes, but nothing too explicit.

Damn, hell, ass heard mildly frequently, and occasionally bitch or biatch.

One possible use of shit in one episode, though it's hard to hear and he might've said "shoot".

Occasionally we see beer, wine, etc, but nothing too bad. Drugs may be discussed.