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Matteo Pellegrinuzzi, a photographer living in Paris, is affected by a primary immunodeficiency, since birth. A bike enthusiast, on July 2019 he decides to undertake a challenge against himself and his condition: riding the 270 km that separate Paris from London in less than 24 hours to bring a message of hope to the patients and their families and to raise awareness on primary immunodeficiencies. The film follows the 8 months of preparation for this venture and is intercalated with the life of three other patients and their daily life.