The word "alcoholic" is used during a parody of the song "99 Bottles of Beer on the Wall".
A walking cigarette is briefly seen.
It is implied that one character is a stoner, with a low IQ and an intelligible speech (younger viewers won't get it). (The guy who takes a picture of Plucky and Hampton and Hampton's family at Happy World Land.)
There is a brief drinking reference where Plucky says: "Call me picky, but isn't that song supposed to be '99 Bottles of Beer on the Wall'?" and Winnie Pig reply's with: "We don't drink in our family, Plucky!"