The characters smoke marijuana, which appears to make them funny, happy, and apt to spontaneously dance in gas station stores; marijuana is presented throughout the movie as something harmless and enjoyable.
There is alot of smoking. Practically every scene has a character with a cigarette in their hand. I felt like I could breathe the smoke throught the TV. There are also a few drug scenes. One in particular stands out. Alcohol is also present but the smoking and drugs completely override it.