Beautiful Losers contains a lot of nudity throughout the film including in photos, film and paintings. Sometimes as a prominent scene but mostly in the background on gallery walls or in the artist's studio. Some photos or paintings portray sexual acts.

This film contains many mild and not so mild swear words. The F-word is used throughout the whole film. Profanity is also used in paintings and other visual media.

The use of alcohol and tobacco is used throughout the film both in film, photos, and art. Drug use is mentioned and at-least one scene has what looked like a bong.