Uses of sexual slurs and terminology.
Scatological humour, including a psychiatrist analyzing his own poop in the toilet by its shape and "duplicoils", uses of the word "turd" and "shit". He tells his wife to get a shoehorn so that they can let the poop "dry in the sun" outside, which they then build a shrine around.
One disability-related mockery; a girl furiously scratching at her head while making pig-like faces is told that she looks like she has down's syndrome.
Frequent vulgar references to sexual anatomy. This includes proper terminology and also slang, including "cunt", "whore", "masturbate", "tampon", "twat", "anal", "oral", "dick", "cock", "fuck" and other words.
Multiple uses of "shit", "fuck", "bitch"; one usage of "svengali", milder words including "poop", "manure", "old maid", "Jesus Christ", "God/oh God" and others.
One of the characters is named Poo. He is a little boy and his teenage mother named him Poo for his habit of defecating on the floor and saying, "I just pooped!" He isn't corrected or punished, rather, the older kids tell him they're proud of him for his behavior.