Some references to assault and rape, in each case clearly in jest.
Profanity
Severe
Very yes. No-holds-barred profanity. Not so much the word choice as much as the context, however.
Alcohol, Drugs & Smoking
Mild
Joke Spoiler: Saget ask the audience if they are drunk or are stoned, or both. He relates to the audience as if they were intoxicated, but never talks about intoxication as a theme in the act.