Fujiko Mine appears naked for roughly half of her screentime, breasts and buttocks exposed in most shots. Her crotch is featureless, however.

Gunshot wounds regularly result in large sprays of blood. An injury is depicted in gruesome detail, with exposed bone and musculature. Multiple head shots result in onscreen death.

Multiple heavy swears such as "asshole", "oh shit" and "son of a bitch" are used in the English dub fairly frequently. Other lighter swears are used as well.

Fujiko is once called a "slut" by the antagonist.

Jigen is always depicted with a lit cigarette in his mouth, and Lupin engages in smoking as well. Multiple characters are shown consuming alcohol.

A graphic injury may disturb viewers unaccustomed to gore.

Fujiko is shown in great peril throughout half of her appearances.